9311-1101 Yost
Yost TJ, Rodgers CM, Eckel RH.
Suction lipectomy: outcome relates to region-specific lipoprotein lipase
activity and interval weight change.
Plast Reconstr Surg. 1993 Nov;92(6):1101-8; discussion 1109-11. PMID: 8234508
Department of Medicine, University of Colorado Health Sciences Center, Denver.
To determine the effects of suction lipectomy on regional adipose tissue
metabolism, nine women had repetitive circumferential measurements and biopsies
of subcutaneous adipose tissue from a lipectomy site (site A) and a nonlipectomy
site (site B) up to 12 months following lipectomy. Maximum reductions from
preoperative baseline in weight, body mass index, and circumferences of sites A
and B occurred at 3 months. Because of variable long-term compliance (6 to 12
months), we created a "last visit" time-point to assess adequately the effects
of lipectomy for each individual. Not all subjects maintained reduction in site
circumferences from 3 months to the last visit. The change in circumference of
site A for that period was highly correlated with the change in circumference of
site B (r = 0.828, p = 0.005). The change in circumference of site B, but not
site A, at 3 months was related to the weight change above the weight of adipose
tissue removed at suction lipectomy. Five subjects who were "sustained
responders" to the lipectomy procedure were able to maintain or decrease
circumferences of sites A and B from 3 months to the last visit. In contrast,
four "limited responders" actually increased circumference of site A and had
either no change or increased circumference of site B from 3 months to the last
visit. The changes in circumference in both sites between 3 months and the last
visit related to changes in body weight over the same interval. Ultimately, the
decrement in circumference of site A was 3.4 percent (-2.4 cm) greater than that
of site B (p = 0.0001). The response to lipectomy in site B, but not site A,
between 3 months and the last visit was related to the change in fasting adipose
tissue lipoprotein lipase from baseline to 3 months (r = 0.728, p = 0.026). This
change in lipase activity in the control region may represent a metabolic
defense of body weight in response to adipose tissue removal in the lipectomy
site.
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