9404-907 Wells
Wells KE, Cruse CW, Baker JL Jr, Daniels SM, Stern RA, Newman C, Seleznick MJ,
Vasey FB, Brozena S, Albers SE, et al.
The health status of women following cosmetic surgery.
Plast Reconstr Surg. 1994 Apr;93(5):907-12. PMID: 8134482
Department of Surgery, University of South Florida College of Medicine, Tampa.
A retrospective study was performed to determine the frequency of new symptoms
and diseases after silicone breast implantation. Questionnaires were mailed to
826 women who made up a breast implant group (n = 516) and a control group who
had undergone blepharoplasty (n = 124), liposuction (n = 111), or rhinoplasty (n
= 75). Responses were obtained from 370 women (45 percent); however, 68 of these
patients (18 percent) were considered ineligible. The overall response rate was
59 percent for the breast implant group and 46 percent for controls. The 302
eligible women included patients with silicone breast implants (n = 222) and
controls (n = 80). Women with implants were significantly younger than controls,
the median age of women with breast implants being 37 years compared with 46.5
years for controls (p < 0.0001). We compared the incidence of 23 symptoms and 4
connective-tissue diseases after cosmetic surgery in the two groups. The
symptoms of swollen glands under arms (p < 0.05) and tender glands under arms (p
< 0.01) were statistically more frequent in the breast implant group. The
symptom change in skin color was more common in the controls (p < 0.001). The
Bonferroni correction for multiple (27) endpoints adjusts the 5 and 1 percent
significance cutoff points to 0.00185 and 0.00037, respectively, leaving only
change of skin color significant at the 5 percent level on the adjusted data. No
cases of scleroderma or lupus were found, and the incidence of arthritis was not
significantly different between the implant and control groups.
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