9606-1379 Burk
Burk RW 3rd, Guzman-Stein G, Vasconez LO.
Lidocaine and epinephrine levels in tumescent technique liposuction.
Plast Reconstr Surg. 1996 Jun;97(7):1379-84. PMID: 8643720
Division of Plastic Surgery, University of Alabama-Birmingham, USA.
The safety of lidocaine dosing in the tumescent technique has been well
documented, but there is little evidence regarding the safety of combining
tumescent lidocaine infiltration with subcutaneous lidocaine infiltration
required in other aesthetic surgery. The safety of lidocaine and epinephrine
dosing was investigated in 10 patients undergoing tumescent technique
liposuction alone and in 10 patients undergoing tumescent liposuction with
concurrent facial and aesthetic breast surgery by determining serum lidocaine
and epinephrine levels at 3, 12, and 23 hours following infiltration of the
tumescent solution and the subcutaneous lidocaine. The mean lidocaine dose of
all patients was 22.3 mg/kg. All patients demonstrated safe lidocaine levels at
all intervals, with the highest levels occurring in patients who received
intravenous lidocaine at the induction of anesthesia. The peak epinephrine
levels occurred at the 3-hour blood draw and were approximately four times
physiologic. No patient demonstrated any subjective or objective signs of
lidocaine or epinephrine toxicity.
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