9705-1591 Samdal
Samdal F, Mollnes TE, Amland PF, Truedsson L.
Modest release of adipsin/factor D by liposuction when using the superwet or tumescent technique.
Plast Reconstr Surg. 1997 May;99(6):1591-4; discussion 1595-6. PMID: 9145127
Department of Plastic Surgery, Trondheim University Hospital, Norway.
Human adipsin is recognized to be identical to factor D, which plays an
important role in activation of the alternative complement pathway. Since
adipsin/factor D is present in high amounts in adipose tissue, liposuction
theoretically could result in an increased release of this serine protease into
the bloodstream. In the present study, adipsin/factor D was measured in 22
patients undergoing syringe-assisted liposuction using the superwet or tumescent
technique. Despite a relatively high mean aspirate volume (2648 ml), only a very
modest increase in adipsin/factor D concentration was found during liposuction.
All values before, during, and after liposuction were within the range found in
healthy blood donors. Furthermore, there was no correlation between
adipsin/factor D values and C3 activation products. We conclude that liposuction
with the present techniques results in a very modest release of adipsin/factor D
that is not associated with increased complement activation.
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