9906-455 Lesser
Lesser T, Ritvo E, Moy LS.
Modification of subcutaneous adipose tissue by a methylxanthine formulation: a
double-blind controlled study. Dermatol Surg. 1999 Jun;25(6):455-62. PMID: 10469092
Comment in:
Dermatol Surg. 1999 Oct;25(10):827.
Dermatol Surg. 1999 Sep;25(9):736.
BACKGROUND: Excessive subcutaneous adipose tissue is typically treated by
physically removing the fat through liposuction, but cost and accessibility have
popularized alternative treatments for reducing adipose tissue thickness.
OBJECTIVE: The purpose of this study was to test the absolute and relative
effectiveness of a liposome-encapsulated caffeine-based cream in modifying
subcutaneous adipose tissue. METHODS: Forty-one patients consented and completed
the double-blind, single-center, placebo-controlled study. Caliper measurements,
tape measurements, and photographs were taken over a 2-month period. RESULTS:
Both concentrations of the cream were found to significantly reduce the
thickness of the adipose tissue in all areas of the body. In addition, the more
concentrated cream was significantly more effective than the less concentrated
cream in the areas of the hips and the triceps. CONCLUSION: The caffeine-based
liposome-encapsulated cream significantly reduced the thickness of the
subcutaneous fat over a 2-month period.
Publication Types:
Clinical Trial
Randomized Controlled Trial
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