| PRS 0404-1391 Kenkel
Kenkel JM, Brown SA, Love EJ, Waddle JP, Krueger JE, Noble D, Robinson JB Jr, Rohrich RJ.
Hemodynamics, electrolytes, and organ histology of larger-volume liposuction in
a porcine model. Plast Reconstr Surg. 2004 Apr 15;113(5):1391-9.
Department of Plastic Surgery, University of Texas Southwestern Medical Center,
Dallas, 75390-9132, USA. jeffrey.kinkel@utsouthwestern.edu
Liposuction is a procedure that allows the surgical removal of excess adipose
tissue in healthy individuals. Lipoplasty is commonly performed with few
clinical side effects. However, with increased lipoaspirate volumes,
complications have been reported. In addition, the abnormal appearance of fat
cells in other tissues subsequent to lipoplasty has been reported in a small
number of cases. The authors examined whether larger-volume lipoplasty, in the
porcine model, resulted in disturbances in cardiac or pulmonary output levels,
electrolytes, and liver chemistry analyses or alterations in organ histology.
Nine adult porcine specimens were subjected to either lipoplasty (n = 6) with
the superwet technique or no lipoplasty (n = 3). Using a Swan-Ganz catheter,
cardiac output and pulmonary artery pressure measurements were obtained from
initial placement before lipoplasty until 48 hours postoperatively. Blood
analyte measurements were obtained. Upon euthanization, liver, kidney, and lung
specimens were collected and tissue sections were prepared. No significant
differences or trends were observed in cardiac parameters or blood analytes
between control and experimental groups. Significant elevations in serum
aspartate aminotransferase and alanine aminotransferase enzyme levels (p < 0.03)
were observed in animals postoperatively (10 to 48 hours) subjected to
lipoplasty compared with controls. Upon gross examination, the lung tissues of
animals subjected to lipoplasty unexpectedly demonstrated patchy petechial
hemorrhages on the pleural surface. Tissue sections revealed marked hemorrhagic
congestion and evidence of pulmonary edema. Fat emboli were also identified
within the pulmonary and renal systems.
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